A summary of or work

Submitting scientific research for peer reviewing  is very important to evaluate and validate our work, and in the wider scheme of things to create novel solutions to complex problems through dialogue with fellow researchers. Below you will find all the work we have published in international journals since 2015.

Al-Sharabi N, Xue Y, Udea M, Mustafa K, Fristad I. Influence of bone marrow stromal cell secreted molecules on pulpal and periodontal healing in replanted immature rat molars. Dental Traumatology 2015; doi: 10.1111/edt. 12246.

Bartaula S, Pedersen TO, Finne-Winstrand A, Bolstad AI, Mustafa K. Angiogenic and Immunomodulatory Properties of Endothelial and Mesenchymal Stem Cells. Tissue Eng Part A. 2015, Dec 9.

Masahito F, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa K. Conditioned media from hypoxic-cultured human dental pulp cells promotes distraction osteogenesis healing through blood vessel enrichment. J Tissue Eng Regen Med. 2015. doi: 10.1002/term.2109.

Suliman S, Xing Z, Wu X, Xue Y, Pedersen TO, Sun Y, Døskeland AP, Nickel J, Waag T, Lygre H, Finne-Wistrand A, Steinmüller-Nethl D, Krueger A, Mustafa K. Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. J Control Release. 2015 Jan 10;197:148-57.

Suliman S, Parajuli H, Sun Y, Johannessen AC, Finne-Winstrand A, McCormack E, Mustafa K, Daniela Costea. Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds. Head and Neck 2015, Aug 14. doi: 10.1002/hed.24187.

Bunæs DF, Lie SA, Enersen M, Aastrøm AN, Mustafa K, Leknes KN. Site specific detrimental tissue responses to cigarette smoking following non-surgical and surgical periodontal therapy. J Clin Periodontol. 2015 26. doi: 10.1111/jcpe.12462.

Mohamed HG, Idris SB, Ahmed MF, Åstrøm AN, Mustafa K, Ibrahim SO, Mustafa M. Influence of type 2 diabetes on local production of inflammatory molecules in adults with and without chronic periodontitis: a cross-sectional study. BMC Oral Health 2015 Jul 27;15:86. doi: 10.1186/s12903-015-0073-z.

Yassin MA, Leknes KN, Pedersen TO, Xing Z, Sun Y, Lie SA, Finne-Wistrand A, Mustafa K. Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration. J Biomed Mater Res A. 2015, doi: 10.1002/jbm.a.35505.

Mohamed HG, Idris SB, Mustafa M, Ahmed MF, Åstrøm AN, Mustafa K, Ibrahim SO. Impact of Chronic Periodontitis on Levels of Glucoregulatory Biomarkers in Gingival Crevicular Fluid of Adults with and without Type 2 Diabetes. PLoS ONE 2015 10: e 0127660.

Westas E, Svanborg LM, Wallin P, Wennerberg A, Mustafa K, Andersson M. Using QCM-D to study adhesion of human gingival fibroblasts on implant surfaces. J Biomed Mater Res A. 2015 Mar 16. doi: 10.1002/jbm.a.35458.

Sun Y, Finne-Wistrand A, Waag T, Xing Z, Yassin M, Yamamoto A, Mustafa K, Steinmüller-Nethl D, Krueger A, Albertsson A-C. Reinforced degradable biocomposite by homogenously distributed functionalized nanodiamond particles. Macromolecular Materials and Engineering 2015 300: 8436-447.

Skodje A, Idris SB, Sun Y, Bartaula S, Mustafa K, Finne-Wistrand A, Wikesjö UM, Leknes KN. Biodegradable Polymer Scaffolds Loaded with Low-Dose BMP-2 Stimulate Cell Differentiation. J Biomed Mater Res A 2015 Jun;103:1991-8. doi: 10.1002/jbm.a.35334.

Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Cell Cotransplantation Strategies for Vascularized Craniofacial Bone Tissue Engineering: A Systematic Review and Meta-Analysis of Preclinical In Vivo Studies. Tissue Eng Part B Rev. 2016 doi:10.1089/ten.teb.2016.0283.

Galli S, Andersson M, Jinno Y, Karlsson J, He W, Xue Y, Mustafa K, Wennerberg A, Jimbo R. Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone. J Biomed Mater Res B Appl Biomater. 2016 doi: 10.1002/jbm.b.33752.

Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Alveolar bone tissue engineering in critical-size defects of experimental animal models: a systematic review and meta-analysis. J Tissue Eng Regen Med 2016 doi: 10.1002/term.2198.

Suliman S, Mustafa K, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T, Nickel J, Johannessen A-Ch, Cormack EM, Costea DE. Nanodiamond modified copolymer scaffolds affects tumour progression. Biomaterials 2016, 95:11-21.

Suliman S, Sun Y, Pedersen TO, Xue Y, Nickel J, Finne-Wistrand A, Steinmüller-Nethl D, Krueger A, Costea DE, Mustafa K. Host response and degradation of copolymer scaffolds functionalised with nanodiamonds and BMP2. Advanced Healthcare Materials 2016, Feb 8. doi: 10.1002/adhm.201500723.

Sharma S, Sapkota D, Xue Y, Sun Y, Finne-Wistrand A, Bruland O, Mustafa K. Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells cultured in 3D Copolymer Scaffolds Enhances Bone Formation. PLoS ONE 2016 25;11(1):e0147507. doi: 10.1371/journal.pone.0147507.

Mohamed HG, Idris SB, Mustafa M, Ahmed MF, Åstrøm AN, Mustafa K, Ibrahim SO. Influence of type 2 diabetes on prevalence of key periodontal pathogens, salivary matrix metalloproteinases and bone remodeling markers in adults with and without chronic periodontitis. Accepted in International Journal of Dentistry (2016).

Yassin MA, Leknes KN, Pedersen TO, Xing Z, Sun Y, Lie SA, Finne-Wistrand A, Mustafa K. Surfactant Tuning of Hydrophilicity of Porous Degradable Copolymer Scaffolds Promotes Cellular Proliferation and Enhances Bone Formation. J Biomed Mater Res A 2016, doi: 10.1002/jbm.a.35741

Al-Sharabi N, Xue Y, Mustafa M, Udea M, Xue Y, Mustafa K, Fristad I. Conditioned media from human bone marrow stromal cells attenuate initial inflammatory reactions in dental pulp tissue. Dental Traumatology 2016; doi: 10.1111/edt. 12277.

Dagmar F Bunæs DF, Lie SA, Aastrøm AN, Mustafa K, Leknes KN. Site-specific effect of smoking following 12 months of supportive periodontal therapy 2016, submitted to J Clin Periodontol.

Rashad A, Mustafa K, Heggset EB, Syverud K. Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry. Biomacromolecules. 2017;18(4):1238-1248. doi: 10.1021/acs.biomac.6b01911.

Yassin MA, Mustafa K, Xing Z, Sun Y, Fasmer KE, Waag T, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Leknes KN. A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration. Macromol Biosci. 2017 Jun;17(6). doi: 10.1002/mabi.201600427.

Shanbhag S, Pandis N, Mustafa K, Nyengaard JR, Stavropoulos A. Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: a systematic review and meta-analysis. J Tissue Eng Regen Med. 2017. doi: 10.1002/term.2412.

Gjerde C, Mustafa K, Hellem S, Rojewski M, Gjengedal H, Yassin MA, Feng X, Skaale S, Berge T, Rosen A, Shi XQ, Ahmed AB, Gjertsen BT, Schrezenmeier H, Layrolle P. Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Stem Cell Res Ther. 2018;9(1):213. doi: 10.1186/s13287-018-0951-9.

Mohamed-Ahmed S, Fristad I, Lie SA, Suliman S, Mustafa K, Vindenes H, Idris SB. Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Res Ther. 2018;9(1):168. doi: 10.1186/s13287-018-0914-1.

Ibrahim M, Schoelermann J, Mustafa K, Cimpan MR. TiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner. J Biomed Mater Res A. 2018 Apr 30. doi: 10.1002/jbm.a.36448.

Helgeland E, Shanbhag S, Pedersen TO, Mustafa K, Rosén A. Scaffold-Based Temporomandibular Joint Tissue Regeneration in Experimental Animal Models: A Systematic Review. Tissue Eng Part B Rev. 2018 Aug;24(4):300-316. doi: 10.1089/ten.TEB.2017.0429.

Sharma S, Sapkota D, Xue Y, Rajthala S, Yassin MA, Finne-Wistrand A, Mustafa K. Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model. Stem Cell Res Ther. 2018 Jan 31;9(1):23. doi: 10.1186/s13287-018-0778-4.

Shanbhag S, Stavropoulos A, Suliman S, Hervig T, Mustafa K. Efficacy of Humanized Mesenchymal Stem Cell Cultures for Bone Tissue Engineering: A Systematic Review with a Focus on Platelet Derivatives. Tissue Eng Part B Rev. 2017;23(6):552-569. doi: 10.1089/ten.TEB.2017.0093

Gjerde CG, De Santis D, Dominici M, Zanotti G, Hellem S, et al. Autologous Porcine Bone Marrow Mesenchymal Cells for Reconstruction of a Resorbed Alveolar Bone: A Preclinical Model in Mini-Pigs. Int J Stem Cell Res Ther 2017; 3:050. doi.org/10.23937/2469-570X/1410050.

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Raja S. Azarudeen, Mohamad Nageeb Hassan, Mohammed Ahmed Yassin, M. Thirumarimurugan, N. Muthukumarasamy, Dhayalan Velauthapillai, Kamal Mustafa, 3D printable Polycaprolactone-gelatin blends characterized for in vitro osteogenic potency, Reactive and Functional Polymers, Volume 146, 2019, 104445, ISSN 1381-5148,

Hassan MN, Yassin MA, Suliman S, Lie SA, Gjengedal H, Mustafa K. The Bone Regeneration Capacity of 3D-Printed Templates in Calvarial Defect Models: A Systematic Review and Meta-Analysis. Acta Biomaterialia 91:1-23. doi: 10.1016/j.actbio.2019.04.017 (2019)

Suliman, S., Ali, H.R.W., Karlsen, T.A. et al. Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells. Sci Rep 9, 16031 (2019). https://doi.org/10.1038/s41598-019-52442-9

Jain S, Fuoco T, Yassin MA, Mustafa K, Wistrand AF. Printability and critical insight into polymer properties during direct- extrusion based 3D printing of medical grade polylactide and copolyesters. Biomacromolecules doi: 10.1021/acs.biomac.9b01112 (2019)

Ahlinder A, Fuoco T, Lopez AM, Yassin MA, Mustafa K, Finne-Wistrand A. Nondegradative additive manufacturing of medical grade copolyesters of high molecular weight and with varied elastic response. Accepted in J Applied Polymer Science (2019)

Fuoco T, Ahlinder A, Jain S, Mustafa K, Wistrand AF. Poly(ε-caprolactone-co-p-dioxanone): a Degradable and Printable Copolymer for Pliable 3D Scaffolds Fabrication toward Adipose Tissue Regeneration, Biomacromolecules 2019 21(1),188-198  DOI: 10.1021/acs.biomac.9b01126

Munir A, Døskeland A, Avery SJ, Fuoco T, Mohamed-Ahmed S, Lygre H, Finne-Wistrand A, Sloan AJ , Waddington RJ, Mustafa K, Suliman S. Journal of Tissue Engineering 31;10:2041731419852703. doi: 10.1177/2041731419852703 (2019).

Sharma S, Xue Y, Xing Z, Yassin MA, Sun Y, Lorens JB, Finne-Wistrand A, Sapkota D, Mustafa K. Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect. Bone Reports 11;10:100205. doi: 10.1016/j.bonr.2019.100205. (2019).

Yassin MA, Fuoco T, Mohamed-Ahmed S, Mustafa K, Finne-Wistrand A. 3D and Porous RGDC-Functionalized Polyester-Based Scaffolds as a Niche to Induce Osteogenic Differentiation of Human Bone Marrow Stem Cells. Macromol Biosci. 2019 May 3:e1900049. doi: 10.1002/mabi.201900049 (2019)

Rojewski MT, Lotfi R, Gjerde C, Mustafa K, Veronesi E, Ahmed AB, Wiesneth M, Körper S, Sensebé L, Layrolle P, Hellem S, Schrezenmeier H. Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data. Cytotherapy 21: 468-482 (2019).

Ojansivu M, Rashad A, Ahlinder AE, Massera J, Mishra A, Syverud K, Finne-Wistrand A, Miettinen S, Mustafa K. Wood-based nanocellulose and bioactive glass modified gelatin-alginate bioinks for 3D bioprinting of bone cells. Biofabrication. doi: 10.1088/1758-5090/ab0692 (2019).

Rashad A, Suliman S, Mustafa M, Pedersen TO, Campodoni E, Sandri M, Syverud K, Mustafa K. Inflammatory Responses and Host Tissue Reactions to Wood-Based Nanocellulose Scaffolds. Materials Science & Engineering C Mater Biol Appl. 97:208-221 (2019).

Shanbhag S, Suliman S, Pandis N, Stavropoulos A, Sanz M, Mustafa K. Cell therapy for orofacial bone regeneration: a systematic review and meta-analysis. J Clin Periodontol doi: 10.1111/jcpe.13049 (2019).

Campodoni E, Heggset EB, Rashad A, Ramírez-Rodríguez GB, Mustafa K, Syverud K, Tampieri A, Sandri M. Polymeric 3D scaffolds for tissue regeneration: Evaluation of biopolymer nanocomposite reinforced with cellulose nanofibrils. Materials Science & Engineering C 94: 867 – 878. doi: 10.1016/j.msec (2019).

Featured cover in JDR

Jain, Shubham, Mohammed Ahmad Yassin, Tiziana Fuoco, Hailong Liu, Samih Mohamed-Ahmed, Kamal Mustafa, and Anna Finne-Wistrand. “Engineering 3D Degradable, Pliable Scaffolds toward Adipose Tissue Regeneration; Optimized Printability, Simulations and Surface Modification.” Journal of Tissue Engineering, (January 2020). https://doi.org/10.1177/2041731420954316.

Shanbhag S, Suliman S, Bolstad AI, Stavropoulos A and Mustafa K (2020) Xeno-Free Spheroids of Human Gingiva-Derived Progenitor Cells for Bone Tissue Engineering. Front. Bioeng. Biotechnol. 8:968. doi: 10.3389/fbioe.2020.00968

Helgeland E, Pedersen TO, Rashad A, Johannessen AC, Mustafa K, Rosén A. Angiostatin-functionalized collagen scaffolds suppress angiogenesis but do not induce chondrogenesis by mesenchymal stromal cells in vivo. J Oral Sci. 2020;10.2334/josnusd.19-0327

Xing Z, Cai J, Sun Y, Cao M, Li Y, Xue Y, Finne-Wistrand A, Kamal M. Altered Surface Hydrophilicity on Copolymer Scaffolds Stimulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells. Polymers (Basel). 2020 Jun 29;12(7):1453. doi: 10.3390/polym12071453. PMID: 32610488; PMCID: PMC7407625.

Omer, A, Al‐sharabi, N, Qiu, Y, et al. Biological responses of dental pulp cells to surfaces modified by collagen 1 and fibronectin. J Biomed Mater Res. 2020; 108: 1369– 1379. https://doi.org/10.1002/jbm.a.36908

Gjerde, C.G., Shanbhag, S., Neppelberg, E., Mustafa, K., & Gjengedal, H. (2020). Patient experience following iliac crest-derived alveolar bone grafting and implant placement. International Journal of Implant Dentistry, 6.

Ingeborg Elisabeth Carlström, Ahmad Rashad, Elisabetta Campodoni, Monica Sandri, Kristin Syverud, Anne Isine Bolstad, Kamal Mustafa, Cross-linked gelatin-nanocellulose scaffolds for bone tissue engineering, Materials Letters, Volume 264, 2020, 127326, ISSN 0167-577X,

Hailong Liu, Astrid Ahlinder, Mohammed A. Yassin, Anna Finne-Wistrand, T. Christian Gasser, Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds, Materials & Design, Volume 188, 2020, 108488, ISSN 0264-1275