3D Printed Engineered Nano-Composite Templates for Bone Regeneration (3DPRENT)

Recent clinical studies performed by our group and other clinical partners in Europe, propose alternatives to conventional treatment modalities by using the concept of tissue engineering in which biomaterials (scaffolds) are used to deliver mesenchymal stem cells (MSC) and/or growth factors. Although there have been some successes, bone tissue engineering needs to overcome several challenges to meet clinical and commercialization needs. Among these challenges, the limitations of scaffolding biomaterials that can resemble macro to nanoscale structures of native bone tissues.

In 3DPRENT, nanocellulose-based hydrogel will be functionalized with nano-hydroxyapatite for osteoconductivity and nanodiamond particles (nDP) to deliver vascular endothelial growth factor (VEGF) to bioprint mesenchymal stem cells (MSC). For mechanical stability and vascularization, hydrogel layers will be reinforced with 3D printed microchannel network of a thermoplastic polymer. 3DPRENT will develop not only outstanding basic scientific knowledge but also sustainable solutions and innovations based on nanotechnology, 3D printing and stem cells thus improving health and promoting new medical technology to meet the needs of society.

The Research Council’s task is to make the best research and innovation possible. Our aim is to promote a society where research is created, used and shared, and thus contributes to restructuring and enhanced sustainability.

The Research Council invests NOK 10 billion in research and innovation annually on behalf of the Norwegian government. It is our task to ensure that this funding goes to the best research and innovation projects.

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